Apples to Apples Niños consists of two decks of cards in Spanish: Red Apple cards (persons, places, things, or events) and Green Apple cards (adjectives). Each turn, the current judge selects a Green Apple card and players try to pick a Red Apple card from their hands that best match that the chosen card. The judge then chooses the Red Apple card is most like the word on the Green Apple card. The judge gives the Green Apple card to the player whose Red Apple card was chosen.

Once a player has won a four Green Apple cards, that player wins.