Based on the 1978 season of the Superfriends TV cartoon.

One player controls the Superfriends (Justice League), the other player controls the Legion of Doom. The game uses a custom card deck for each player. Each deck includes Character Cards and Plot Cards.

To win a hand a player must play Plot and Character cards having a higher total Power Value than the cards played by the opposing player. The first player to win a total of seven hands wins the game.