Each player is an American Christian missionary with the goal of visiting a number of countries on short-term mission trips. Various cards that are drawn poke fun of common experiences of those who go on short-term mission trips, including setbacks in raising money to go on the trip, and (in another country) finding out that the local cuisine does not agree with your stomach.

If you're behind in the game, you can go to a country that does not welcome outside religions - if you are martyred you get an extra bonus. You'd be out of the game but might win posthumously.