An Icehouse games in which players alternate turns playing pieces onto a 5×6 grid. Each piece must be played in the spot "pointed to" by the previous piece, and must point at an empty square. The first player to be unable to make a valid move, loses.

Synapse-Ice was designed by Joseph Kisenwether and tied for 4th in the Winter 2005 Icehouse Game Design Competition. It was inspired by Pierre Berloquin's Synapse.

The rules are available online.